Podolski returns to the starting lineup after missing Sunday’s 2-1 defeat at Chelsea because of illness and will join Theo Walcott and Olivier Giroud.
Alex Oxlade-Chamberlain is also on the bench, while Abou Diaby (thigh) is rested and Francis Coquelin (hamstring) missing out as well.
Carlton Cole will lead the West Ham United attack, but former Chelsea and Liverpool midfielder Joe Cole is only amongst the substitutes.
On-loan striker Marouane Chamakh was not in the squad as he is ineligible to play against his parent club Arsenal.
Arsenal v West Ham
Arsenal: Szczesny, Sagna, Mertesacker, Vermaelen, Gibbs, Ramsey, Wilshere, Cazorla, Walcott, Giroud, Podolski
Subs: Mannone, Koscielny, Andre Santos, Oxlade-Chamberlain, Arshavin, Jenkinson, Frimpong
West Ham: Jaaskelainen, Demel, Tomkins, Reid, O’Brien, Noble, Nolan, Collison, Taylor, Carlton Cole, Vaz Te
Subs: Henderson, Jarvis, Diame, Diarra, Joe Cole, O’Neil, Potts
Referee: Andre Marriner