Ronaldo has been in sparkling form for the Spanish champions this season and is tipped to continue his good run for the national this summer.
Ricardo Quaresma and Hélder Postiga start alongside the tricky frontman in the attack, while João Moutinho and Miguel Veloso both start in midfield.
Nani is on the sub-bench with Pepe, Ricardo Costa, Nelson Castro Oliveira and Hugo Almeida.
Portugal vs FYR Macedonia
Portugal: Beto, Joao Pereira, Bruno Alves, Rolando, Fabio Coentrao, Veloso, Ruben Micael, Joao Moutinho, Postiga, Quaresma, Ronaldo
Subs: Eduardo, Pepe, Custodio, Almeida, Nelson Oliveira, Miguel Lopes, Meireles, Nani, Varela, Ricardo Costa, Hugo Viana, Rui Patricio
FYR Macedonia: Bogatinov, Grncarov, Noveski, Sikov, Ristovski, Urdinov, Gligorov, Spirovski, Trickovski, Fazli, Pandev
Subs: Nuredinovski, Georgievski, Mojsov, Demiri, Hasani, Tairi, Ibraimi, Ivanovski, Muarem
Referee: Alan Kelly (Ireland)