Kick-off time for this contest is set for 7:30 pm ET, with live online streaming and television coverage. WatchESPN, ESPN3 and WatchABC will provide the stream, with ABC taking care of the TV action.
Chris Fowler, Kirk Herbstreit and Maria Taylor will make the call.
Heisman Trophy candidates Baker Mayfield and J.T. Barrett will lead their respective team from the ESPN College GameDay location.
The game will also be the first road contest under rookie head coach Lincoln Riley, who turned 34 on Tuesday and is the youngest FBS head coach.
The Sooners are coming off a 56-7 home victory over UTEP in Week 1 when they tallied 676 yards of offense.
Mayfield went 19 of 20 for 329 yards and three touchdowns, playing only the first half for OU.
Meanwhile, Barrett was 20 of 35 from completed passes for 304 yards and three touchdowns, while running for another 61 yards and a score in the 49-21 victory posted by Ohio State over Indiana in Week 1.
Coach Urban Meyer revealed that freshman running back J.K. Dobbins, who started the season opener against the Hoosiers, will start against Oklahoma, although Mike Weber is healthy again for the Buckeyes.
Weber was the starting running back last season but had been sidelined with a hamstring injury.
Meyer said the sophomore is ready to play again but he will reward Dobbins for his impressive college debut by sticking with the college rookie in the starting team after he set a school record for a freshman in a season opener with 181 rushing yards.
“(Mike) practiced this week. He’s good to go,” Meyer confirmed. “We’ll play him.
“To say he’s gonna have so many carries, we have no idea. J.K. will start and we’ll see as we move forward.”
Meyer added that both players will definitely feature.
“You’ll see them both,” he said. “I’m really excited about it.”
Meanwhile, former Oklahoma Sooners head coach Bob Stoops, who retired this summer, is in Columbus and is expected to be at the game on Saturday night.
Cornerstone programs meet tonight. Oklahoma and Ohio State. Here we go.