Maguire struck to give Manchester United the lead with a beautiful strike from outside the edge of the box in the 10th minute of play.
He smartly broke forward and dribbled past David Perkins before releasing a shot from 20-yards, which dipped beautifully into the top corner following a deflection off Peter Clarke’s head.
It was the first goal for the England defender and club captain since his big-money move from Leceister City in the summer transfer window.
Manchester United scored three goals in six minutes to take complete control of this FA Cup tie on a patched-up field at Prenton Park.
The English Premier League side score five goals in a rampant first half.
Adding to the scoring as well were right-back Diogo Dalot, midfielder Jessie Lingard and center-back Phil Jones, who headed home his first FA Cup goal, minutes before halftime. Forward Anthony Martial added a fifth right before the break.
Manchester United Scorers: H Maguire (10),D Dalot (13),J Lingard (16),P Jones (41),A Martial (45)
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Brilliant! Isn't it. Be bless.