In comes Antonio Valencia, Ashley Young and Tom Cleverley, while Marouane Fellaini starts on the bench along with Danny Welbeck and Shinji Kagawa.
There is not Juan Mata, who is not available because of cup tie, while there is also no Adnan Januzaj in the United squad for the clash.
Ryan Giggs starts on the bench, while Rio Ferdinand and Nemanja Vidic lead the backline.
Former Barcelona striker Javier Saviola misses out for Olympiakos with injury, but on loan Arsenal attacker Joel Campbell starts.
Olympiakos v Manchester United
Olympiakos: Roberto, Leandro Salino, Manolas, Marcano, Holebas, Maniatis, Ndinga, Campbell, Dominguez, Perez, Olaitan. Subs: Megyeri, Paulo Machado, Samaris, Haedo Valdez, David Fuster, Papadopoulos, Bong Songo.
Man Utd: De Gea, Smalling, Ferdinand, Vidic, Evra, Cleverley, Carrick, Valencia, Rooney, Young, van Persie. Subs: Lindegaard, Giggs, Hernandez, Welbeck, Kagawa, Buttner, Fellaini.
Referee: Gianluca Rocchi (Italy)