Preseason favourites Manchester City will be in action in Monday Night Football.
The game of the week in Week 2 is unquestionably the battle between London rivals Tottenham and Chelsea — two teams among the bookies frontrunners to win the English Premier League this season.
Spurs eased to a comfortable 2-0 victory over Newcastle United in Week 1, while the Blues, still very unsettled by the Diego Costa situation, were reduced to nine-players in a 3-2 defeat to Burnley FC at Stamford Bridge.
Kick-off time for this game on Sunday is set for 11:00 am ET at Wembley Stadium.
Meanwhile, after the impressive outing in Week 1 against West Ham United at home, Manchester United will try to replicate that performance on the road against Swansea City in an early kick-off.
At Old Trafford last week, the Red Devils blew away the Hammers 4-0, with summer recruit Romelu Lukaku scoring twice on his debut.
Swansea City played to a scoreless draw with Southampton on the opening week, but could find it very difficult against a Manchester United side that is determined to win the league this season.
In other English Premier League fixtures on Saturday, Arsenal, following the late thrilling 4-3 win over Leicester City last Friday, will travel to take on Stoke City, while Liverpool will try to bounce back from the disappointing 3-3 draw with Watford when they host Crystal Palace.
Elsewhere, Bournemouth will play Watford, Burnley play host to West Bromwich Albion, West Ham United go on the road again to square off with Southampton, while Leicester City will entertain Brighton and Hove Albion.
English Premier League Fixtures In Week 2
All Game Times In EST
Saturday, August 19
Swansea City v Manchester United (7:30 am)
Bournemouth v Watford (10:00 am)
Burnley v West Bromwich Albion (10:00 am)
Leicester City v Brighton and Hove Albion (10:00 am)
Liverpool v Crystal Palace (10:00 am)
Southampton v West Ham United (10:00 am)
Stoke City v Arsenal (12:30 pm)
Sunday, August 20
Huddersfield Town v Newcastle United (8:30 am)
Tottenham Hotspur v Chelsea (11:00 am)